Seven-time Wimbledon champion Roger Federer begins his quest for an 18th Grand Slam title with an opening round encounter against Romania's Victor Hanescu, while the man who beat him at this venue in last year's Olympic final Andy Murray takes on Germany's Benjamin Becker in his opener.
Fifth seeded Nadal will be up against Belgian Steve Darcis in his first round match as he looks to extend his 22-match winning streak.
2004 ladies' singles champion Maria Sharapova is the third seeded for this year's tournament and in Kristina Mladenovic faces a tough opponent she has never played before.
Other noteworthy matches on the opening day of Wimbledon 2013 include French Open semi-finalist Jo-Wilfried Tsonga's clash with David Goffin, former champion Petra Kvitova's match with Coco Vandeweghe and 11th seeded Stanislas Wawrinka encounter with in-form 2002 champion Lleyton Hewitt.
Elsewhere on Monday, the women's under 20 world volleyball championships continue, whilst there's also Challenger Series table tennis and Eurobasket action to take in.
04:00 - SOCCER - Chivas USA v LA Galaxy
07:30 - TABLE TENNIS - Kathrin Muehlbach vs Jessica Göbel
08:10 - TABLE TENNIS - Tanja Kraemer vs Jennifer Jonsson
08:50 - TABLE TENNIS - Andrea Bakula vs Olga Nemes
09:30 - TABLE TENNIS - Dana Cechova vs Alex Galic
10:05 - RUGBY LEAGUE - Gold Coast Titans v Melbourne Storm
10:10 - TABLE TENNIS - Kathrin Muehlbach vs Tanja Kraemer
10:50 - TABLE TENNIS - Andrea Bakula vs Jennifer Jonsson
10:55 - TENNIS - Challenger Marburg
11:00 - SOCCER - Jeonbuk KSPO Women v Suwon FMC Women
11:30 - TABLE TENNIS - Dana Cechova vs Olga Nemes
11:30 - VOLLEYBALL - Dom Rep U20 Women vs Chinese Taipei U20 Women
11:30 - TENNIS - Wimbledon
11:45 - VOLLEYBALL - USA U20 Women vs Mexico U20 Women
12:10 - TABLE TENNIS - Alex Galic vs Jessica Göbel
12:50 - TABLE TENNIS - Kathrin Muehlbach vs Andrea Bakula
13:00 - BASKETBALL - Montenegro Women vs Italy Women
13:30 - TABLE TENNIS - Tanja Kraemer vs Jessica Göbel
14:00 - VOLLEYBALL - China U20 Women vs Thailand U20 Women
14:00 - VOLLEYBALL - Italy U20 Women vs Algeria U20 Women
14:10 - TABLE TENNIS - Dana Cechova vs Jennifer Jonsson
15:30 - SOCCER - MFK Kosice v Torpedo Kutaisi
15:30 - BASKETBALL - Sweden Women vs Slovak Rep Women
16:15 - VOLLEYBALL - Brazil U20 Women vs Russia U20 Women
16:30 - VOLLEYBALL - Czech Rep U20 Women vs Peru U20 Women
16:30 - SOCCER - FK Tauras v Pakruojo Kruoja
18:00 - SOCCER - Acharnaikos v Brommapojkarna
18:00 - SOCCER - Gefle IF v Djurgarden
18:00 - SOCCER - IFK Goteborg v Mjallby
18:00 - SOCCER - Malmo FF v Elfsborg
18:00 - SOCCER - Osters IF v IFK Norrkoping
18:30 - VOLLEYBALL - Turkey U20 Women vs Egypt U20 Women
19:00 - VOLLEYBALL - Serbia U20 Women vs Japan U20 Women
19:00 - BASKETBALL - Spain Women vs Turkey Women
21:00 - SOCCER - Breidablik v Valur Reykjavik
