Ireland head coach Declan Kidney made 12 changes to his side to play Fiji in a non-Test fixture at Thomond Park on Saturday.
Captain Jamie Heaslip, Mike Ross and Conor Murray are the only players selected who started last weekend's narrow defeat to South Africa.
The uncapped Ulster trio - inside centre Luke Marshall, wing Craig Gilroy and fly-half Paddy Jackson - have all been selected to face Fiji.
"We know it will be a difficult test and this is a vote of confidence for the players we've picked," coach Declan Kidney said.
"We know they'll do a job and they've been training really well over the last two and a half weeks. We feel they deserve their go."
Ireland will face Argentina in the climax to their Guinness Series on Saturday week.
Ireland XV to play Fiji: D Hurley; F McFadden, D Cave, L Marshall, C Gilroy; P Jackson, C Murray; D Kilcoyne, S Cronin, M Ross, D O'Callaghan, D Tuohy, I Henderson, J Muldoon, J Heaslip
Replacements: R Strauss, C Healy, M Bent, D Ryan, C Henry, P Marshall, J Sexton, S Zebo
Ireland are as short as 1/66 to win the match outright but 10/11 to beat the handicap of 23 points with
Paddy Power. Fiji are 14/1 to win the match and 10/11 with a 23 point head start.
Handicap Betting
Ireland XI (-23.0) 10/11
Draw (-23.0) 22/1
Fiji (+23.0) 10/11